LP18489-2
Glutamate decarboxylase 65
Active
Description
Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells and by circulating autoantibodies against a variety of islet cell antigens including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA). GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. PMID: 7532143 GAD65 antibodies are specific to patients with insulin-dependent diabetes. The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years. PMID: 11114103 GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) GAD65 are also associated with paraneoplastic neurologic syndrome (PNS) which is an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. In addition, the different PNS antibodies are associated with certain cancers and can assist in identifying where an unknown tumor is located. PMID: 22412264 Glutamic acid decarboxylase 65 antibody are associated with stiff person syndrome, cerebellar ataxia encephalitis and other neurological diseases. PMID: 22405456 Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- Glutamate decarboxylase 65
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- GAD65
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 谷氨酸脱羧酶-65 Synonyms: GAD65; |
| fr-CA | French (Canada) | Glutamate décarboxylase 65 |
| et-EE | Estonian (Estonia) | Glutamaadi dekarboksülaasi 65 vastased |
| es-ES | Spanish (Spain) | Glutamato decarboxilasa 65 |
| it-IT | Italian (Italy) | Glutammato decarbossilasi 65 Synonyms: GAD65 |
| tr-TR | Turkish (Turkey) | Glutamat dekarboksilaz 65 |
| ru-RU | Russian (Russian Federation) | Глутаматдекарбоксилаза 65 |
| nl-NL | Dutch (Netherlands) | glutamaatdecarboxylase 65 |
| fr-BE | French (Belgium) | Glutamate décarboxylase 65 |
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