LP188416-4
Sheep prion protein codon 112
Active
Description
Scrapie is a fatal, degenerative disease affecting the central nervous system of sheep and goats. It is in the same class of diseases as BSE in cattle and Chronic Wasting Disease in elk and deer. Transmission of the classical scrapie agent is not completely understood but apparently healthy sheep infected with the agent can transmit disease. Sheep and goats are typically infected as young lambs or kids, though adult sheep and goats can become infected. The infecting agent or prion is a mal-formed version (PrPsc ) of a normal protein (PrP) found in all animals. The malformation of the normal prion proteins occurs when they are exposed to the mal-formed version of the protein. The normal prion proteins may be more or less susceptible to malformation when they are exposed to the mal-formed protein based on their genetic makeup. Resistance or susceptibility has been linked to the presence of certain amino acids at various locations within the normal protein. Genotyping determines the amino acids present at specific locations or codons in the prion protein. These are reported as a pair of one character amino acid codes such as RR, RH, QQ, etc. This testing does not diagnosis Scrapie, but is an important tool for selecting genetically resistant animals for breeding and eradication. Codons associated with susceptibility/resistance to scrapie include codon 112, 136, 141, 154 and 171. Codon 112 codes for either methionine (M) or threonine (T). The presence of T at codon 112 has been associated with increased resistance to scrapie. Source: American Association of Veterinary Laboratory Diagnosticians
Basic Part Properties
- Part Name
- Sheep prion protein codon 112
- Part Display Name
- Sheep prion protein codon 112
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2014-12-22
- Construct for LOINC Short Name
- Sheep PrP codon 112
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP188416-4
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 绵羊朊蛋白密码子 112 Synonyms: 绵羊朊蛋白（朊病毒蛋白）密码子 112 |
| es-ES | Spanish (Spain) | proteína priónica en oveja, codon 112 |
| it-IT | Italian (Italy) | Pecora, proteina prionica codone 112 |
| tr-TR | Turkish (Turkey) | Koyun prion proteini kodon 112 |
| nl-NL | Dutch (Netherlands) | schapen prionproteïne codon 112 |
| pl-PL | Polish (Poland) | Białko prionowe owcy kodon 112 |
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://