Version 2.77

Descriptions

Found on Platelets and megakaryocytes
Associated with AML M7. Absent in Glanzmann's thrombasthenia Source: Regenstrief LOINC

Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), also known as ITGA2B, is a human gene.

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Mutations that interfere with this role result in thrombasthenia. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, CD41

Basic Part Properties

Part Display Name
CD41
Part Type
Fragments For Synonyms
Created On
2000-05-08
Construct for LOINC Short Name
CD41

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP20078-9

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) CD41
Synonyms: alpha IIb 整合素链;GPⅡb;GPIIb;α Ⅱb 整合素链;发现于血小板和巨核细胞之上。与急性髓系白血病 M7（AML M7）相关。血小板无力症（Glanzmann's thrombasthenia，GT，Glanzmann 血小板机能不全，血小板衰弱症）时缺如。;糖蛋白 ⅡB;糖蛋白 IIB;糖蛋白 IIB（Glycoprotein IIB，GPIIb）