LP201655-0
2-Methyltyrosine
Active
Description
Metyrosine is only found in individuals that have used or taken this drug. It is an inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed)Metyrosine inhibits tyrosine hydroxylase, which catalyzes the first transformation in catecholamine biosynthesis, i.e., the conversion of tyrosine to dihydroxyphenylalanine (DOPA). Because the first step is also the rate-limiting step, blockade of tyrosine hydroxylase activity results in decreased endogenous levels of catecholamines and their synthesis. This consequently, depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body,usually measured as decreased urinary excretion of catecholamines and their metabolites. One main end result of the catecholamine depletion is a decrease in blood presure. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Metyrosine
Basic Part Properties
- Part Name
- 2-Methyltyrosine
- Part Display Name
- 2-Methyltyrosine
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2015-10-20
- Construct for LOINC Short Name
- 2Me-tyrosine
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP201655-0
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 2-甲基酪氨酸 |
| es-ES | Spanish (Spain) | 2-Metiltirosina |
| it-IT | Italian (Italy) | 2-Metiltirosina |
| tr-TR | Turkish (Turkey) | 2-Metiltirozin |
| nl-NL | Dutch (Netherlands) | 2-methyltyrosine |
LOINC Copyright
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