Version 2.78

Description

Changes in the CSF, plasma and urine levels of beta alanine, beta aminoisobutyrate (BAIB) and gamma aminobutyrate (GABA) may help identify certain metabolic disorders. Beta alanine is a structural analogue of GABA and may also function as a neurotransmitter since it is both a glycine and GABAA receptor agonist. Dihydropyrimidine dehydrogenase (DPD) is the first enzyme in the pyrimidine degradation pathway, in which uracil and thymine are catabolized to beta alanine and R-BAIB, respectively. The S enantiomer of BAIB (S-BAIB) is derived from valine catabolism. Under normal circumstances, urine contains predominantly R-BAIB (from thymine) because it is eliminated by filtration and tubular secretion, while plasma contains about 80% S-BAIB (from valine), which is reabsorbed in the kidneys. In patients with a DPD deficiency, uracil and thymine catabolism is decreased. This results in mildly decreased plasma and urine concentrations and normal CSF concentration of beta alanine, and moderately decreased CSF concentration and markedly decreased plasma concentration of BAIB. On the other hand, urine BAIB is elevated, which indicates that there must be cross-over in the thymine and valine degradation pathways. PMID: 14705962 Source: Regenstrief LOINC, PMID: 14705962

Basic Part Properties

Part Display Name
Beta alanine and Beta aminoisobutyrate and Gamma aminobutyrate pattern
Part Type
Component (Describes the core component or analyte measured)
Created On
2015-10-21
Construct for LOINC Short Name
B-Alanine + B-AIB + GABA patt

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP201667-5

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) Beta 丙氨酸与 Beta 氨基异丁酸与 Gamma 氨基丁酸模式
Synonyms: Beta 丙氨酸（β丙氨酸、β-丙氨酸）与 Beta 氨基异丁酸（β氨基异丁酸、β-氨基异丁酸）与 Gamma 氨基丁酸（γ氨基丁酸、γ-氨基丁酸）模式（模式特征、特征模式、图谱、式样、组份、组分、成员）
es-ES Spanish (Spain) Patrón de Beta alanina y Beta aminoisobutirato y Gamma aminobutirato
it-IT Italian (Italy) Beta alanina & Beta aminoisobutirrato & Gamma aminoisobutirrato, profilo
Synonyms: Profilo di Beta alanina & Beta aminoisobutirrato &
tr-TR Turkish (Turkey) Beta alanin ve Beta aminoizobütirat ve Gamma aminobutirat örüntüsü
Synonyms: Beta alanin ve Beta aminoizobütirat ve Gamma aminobutirat paterni
nl-NL Dutch (Netherlands) bèta-alanine & bèta-aminoisobutyraat & gamma-aminobutyraat patroon
Synonyms: beta alanine & Beta aminoisobutyraat & Gamma aminobutyraat patroon