Version 2.78

Description

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene [HGNC Gene ID: 2645]. Variations in the SLCO1B1 gene have been significantly associated with a marked increase in systemic exposure to simvastatin and risk of muscle toxicity. PMID: 24918167 The overall effect size and significance of this association are striking for simvastatin compared to other statins. Patients with variations in SLCO1B1 (a transporter of simvastatin) may require a lower simvastatin dose or an alternative statin as compared to patients who do not have this variant. See https://www.pharmgkb.org/gene/PA134865839 for more information and dosing guidelines for drugs impacted by SLCO1B1 genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

Basic Part Properties

Part Display Name
SLCO1B1 gene product functional interpretation
Part Type
Component (Describes the core component or analyte measured)
Created On
2015-11-09
Construct for LOINC Short Name
SLCO1B1 gene prod fnc imp

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP202928-0

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) SLCO1B1 基因产物功能解释
Synonyms: SLCO1B1 基因产物功能（功能性、功能活性）解释（说明、阐释、诠释、解释说明）
es-ES Spanish (Spain) Gen SLCO1B1 interpretación de la función del fármaco
it-IT Italian (Italy) Interpretazione funzionale del gene SLCO1B1
tr-TR Turkish (Turkey) SLCO1B1 geni ürünü fonksiyonu yorumu
nl-NL Dutch (Netherlands) SLCO1B1-gen product functionele interpretatie
Synonyms: SLCO1B1 gen product functionele interpretatie