Version 2.77

Descriptions

Dilute Russell viper venom time (dRVVT) is used most commonly as one of the screening tests to diagnose lupus anticoagulants (LA), which are phospholipid autoantibodies associated with excess clot formation, excess bleeding, and repeated miscarriages. The coagulant in the venom directly activates factor X, which turns prothrombin into thrombin in the presence of factor V and phospholipid. If phospholipid antibodies are present, this reaction will be inhibited, which will prolong the dRVVT and suggests the presence of LA. PMID: 19624461 Source: Regenstrief LOINC, PMID: 19624461

Dilute Russell's viper venom time (dRVVT) is a laboratory test for lupus anticoagulant (LA). This in vitro diagnostic test is based on the property that the venom of the Russell's Viper is effective at inducing thrombosis. The coagulant in the venom directly activates factor X, which turns prothrombin into thrombin in the presence of factor V and phospholipid. The venom is diluted to give a clotting time of 23 to 27 seconds and the phospholipid is reduced to make the test extremely sensitive to phospholipid. The dRVVT test is more sensitive than the aPTT test for the detection of lupus anticoagulant (an autoimmune disorder), because it is not influenced by deficiencies in clotting factors VIII, IX or XI. The dRVVT is thought to be more sensitive than the activated partial thromboplastin time (aPTT) for detection of lupus anticoagulants. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Dilute Russell viper venom time (Wikipedia)

Basic Part Properties

Part Display Name
dRVVT
Part Type
Multipart
Created On
2000-12-18

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Tag Language Translation
zh-CN Chinese (China) 稀释蝰蛇毒时间
Synonyms: DDRVTVT