Version 2.78

Description

Neutrophils are white blood cells that are critical to the healthy function of the immune system. They are drawn to sites of infection and injury to phagocytose and digest microbes. PMID: 22224774 Neutrophils rely on their ability to generate an oxidative burst to effectively kill microorganisms. The oxidative burst is a series of reactions involving NADPH oxidase that is triggered by receptors when they encounter bacterial peptides such as N-formyl-Met-Leu-Phe (fMLP) and phorbol myristate acetate (PMA) and which results in the production of superoxide anions and reactive oxygen species (ROS). PMID: 22262438 PMID: 10733101 The inability of neutrophils to create an oxidative burst can lead to a decreased ability to fight infection. Chronic granulomatous disease (CGD) is an x-linked or autosomal-recessive disorder where NADPH oxidase is improperly assembled which leads to an inadequate oxidative burst response and increased susceptibility to bacterial and fungal infections. PMID: 22262438 One method of assessing neutrophil function uses flow cytometry to measure the fluorescence of neutrophils that have been stimulated in the presence of the nonfluorescent dye dihydrorhodamine 123 (DHR 123), which, when oxidized, produces the fluorescent compound rhodamine 123. Both the percent of neutrophils having a burst response and the efficacy of that response as reflected by the mean fluorescence intensity (MFI) is measured. Depending on the underlying genetic cause and severity of CGD, some patients have a population of neutrophils that can generate a burst response but with lower MFI compared to healthy controls, while others only have neutrophils that are not capable of generating a response at all. PMID: 26912782 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Neutrophil.fMLP stimulated.DHR
Part Type
Component (Describes the core component or analyte measured)
Created On
2017-01-06
Construct for LOINC Short Name
Neut.fMLP DHR

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP247787-7

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Neutrofilos.Estimulación con fMLP.DHR (dihidrorodamina)
zh-CN Chinese (China) 嗜中性粒细胞.经 fMLP 刺激.DHR
Synonyms: 嗜中性粒细胞（中性、中性粒、中性粒细胞、嗜中性、Neu）.经 fMLP（N-formyl-Met-Leu-Phe、N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸） 刺激.DHR（二氢罗丹明、二氢罗丹明 123、dihydrorhodamine 123、DHR 123）
it-IT Italian (Italy) Neutrofili.stimolati da fMLP.DHR
nl-NL Dutch (Netherlands) neutrofielen.fMLP gestimuleerd.DHR
pl-PL Polish (Poland) Neutrofil.stymulowany fMLP.DHR
Synonyms: Odpowiedź neutrofilów po stymulacji na N-formylo-metionylo-leucylo-fenyloalaninę (fMLP), DHR