Version 2.80

Description

Thymidine synthase is the enzyme that catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) using the methyl donor 5,10-methylenetetrahydrofolate (CH2THF) as a cofactor. dTMP is critical for DNA repair and replication. Thymidine synthase has become the target for drugs used in the treatment of some cancers including the drug 5-fluorouracil (5-FU). The active metabolite of 5-FU combines with the nucleotide binding site of TS which prevents dUMP from being able to bind with TS. The decreased amount of dUMP leads to decreased cell replication. Studies have shown that the gene amplification of TS in the tumor cells correlate to resistance to 5-FU. http://www.nature.com/nrc/journal/v3/n5/fig_tab/nrc1074_F2.html Source: Regenstrief LOINC

Basic Part Properties

Part Name
Thymidine synthase activity interpretation
Part Display Name
Thymidine synthase activity interpretation
Part Type
Component (Describes the core component or analyte measured)
Created On
2017-03-24
Construct for LOINC Short Name
TS act interp

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP248780-1

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Actividad timidina sintetasa, interpretación
it-IT Italian (Italy) Timidina, interpretazione dell'attività di sintesi
Synonyms: Interpretazione dell''attività di sintesi della tim
zh-CN Chinese (China) 胸苷合成酶活性解释
Synonyms: 胸苷（胸腺嘧啶脱氧核苷）合成酶（合酶）活性解释（说明）
el-GR Greek (Greece) Ερμηνεία δραστηριότητας της συνθάσης της θυμιδίνης
Synonyms: Ερμηνεία δραστηριότητας της συνθάσης της θυμιδίνης