LP263522-7
Clostridioides difficile BI-NAP1-027 strain
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Description
Clostridium difficile (CD) infections in hospitals across the United States, Canada and Europe experienced an enormous increase between 2000 and 2006. The pathogen that was found to cause this outbreak was the strain of CD determined by restriction endonuclease analysis (REA) to be toxin type III, restriction endonuclease analysis (REA) group B1; by pulsed-field gel electrophoresis as North American pulsed-field type NAP1; and by polymerase chain reaction (PCR) ribotyping as type 027. The strain is identified as Clostridium difficile BI/NAP1/027 or NAP1. The NAP1 strain of CD produces increased levels of three toxins, the usual toxins A and B, and a binary toxin. A mutation of the toxin A and B suppressor gene tcdC may explain the increased production of toxin. It is also strongly resistant to treatment with fluoroquinolone antibiotics. CD NAP1 is not a new strain of CD. It was isolated between 1984 and 1992 and is identical to the strain isolated is the 2000s, except that the original CD NAP1 strain was not resistant to the new fluoroquinolone drugs of the time, which included gatifloxacin and moxifloxacin. Risk factors for infection with CD NAP1 include advanced age, hospitalization, and exposure to antibiotics, notably fluoroquinolones and cephalosporins. The elderly are especially vulnerable to infection, and have a 30-day mortality rate of more than 5%. PMID: 19457419 Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- Clostridioides difficile BI-NAP1-027 strain
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2017-09-19
- Construct for LOINC Short Name
- C diff BI NAP1 027
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Cepa BI-NAP1-027 Clostridium difficile |
| it-IT | Italian (Italy) | Clostridium difficile BI-NAP1-027, variante Synonyms: Variante clostridium difficile BI-NAP1-027 |
| zh-CN | Chinese (China) | 艰难梭菌 BI-NAP1-027 株 Synonyms: 艰难梭菌（艰难梭状芽胞杆菌、 |
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