Version 2.78

Descriptions

Dengue viruses are in the Flavivirus genus of the Flaviviridae family. Flaviviruses are enveloped, single-strand RNA viruses. The genomic RNA encodes three structural proteins, C (core protein), M (membrane protein), and E (envelope protein). The nonstructural (NS) proteins are NS1, NS2a, NS2b, NS3, NS4a, NS4b, and NS5. NS1 is a glycoprotein that appears to be essential for virus viability but has no established biological activity. NS1 is produced in both membrane-associated and secreted forms. The NS1 antigen is present at high concentrations patients during the early clinical phase of the disease. PMID: 16988003 Source: Regenstrief LOINC, PMID: 16988003

Dengue is caused by any one of four distinct but closely related dengue virus (DENV) serotypes (DENV-1, -2, -3, and -4), which are single-stranded RNA viruses in family Flaviviridae, genus Flavivirus. This family includes other important vector-borne viruses (e.g., West Nile virus, Yellow Fever virus, Japanese Encephalitis virus, St. Louis Encephalitis virus, etc.). Dengue viruses are arboviruses (arthropod-borne virus) transmitted primarily to humans through an infected Aedes species mosquito bite. Transmission may also occur through transfusion of infected blood or transplantation of infected organs or tissues or after occupational exposure in healthcare settings. All four dengue serotypes can produce the full spectrum of illness and severity. The spectrum of illness can range from a mild febrile syndrome to classic dengue fever (DF), to the severe forms of the disease, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Diagnosis can include serology, antigen detection or molecular testing. PCR assays have been devloped that target various areas of the genome including genes for non-structured proteins, the capsid protein, or the 3' or 5' untranslated regions. Source: Regenstrief LOINC, CDC: Dengue

Basic Part Properties

Part Display Name
Dengue virus Ab.IgG and IgM and NS1 Ag panel
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-07-30
Construct for LOINC Short Name
Dengue virus Ab.IgG + IgM + NS1 Ag panel

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