Version 2.80

Description

Parathyrin 1-84 (PTH (1-84)) is the biologically active hormone that regulates the calcium and phosphate levels in the circulation. PTH (1-84) is originally produced as a 118-amino acid polypeptide in the parathyroid glands. It is cleaved twice to form a functional 84-amino acid peptide that is stored in the parathyroid cells. The first 34 amino acids bind to the type 1 PTH/PTH-related peptide receptor that is expressed primarily in bone, kidney, cartilage, vessels, and certain developing organs. PMID: 26303600 The half-life of PTH (1-84) is 2-4 minutes, after which it is degraded into a carboxyl (C)- or amino (N)-terminal fragment. The C-fragments have a half-life of 5-10 minutes, are cleared by the kidneys, and can accumulate in the circulation during chronic kidney disease. Some evidence suggests that N-terminally truncated fragment PTH (7-84) may interact with receptors that regulate bone resorption and serum calcium concentrations that could lead to the quantification of other PTH fragments.[https://www.uptodate.com/contents/parathyroid-hormone-assays-and-their-clinical-use] Source: Regenstrief LOINC

Basic Part Properties

Part Name
Parathyrin.1-84
Part Display Name
Parathyrin.1-84
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-08-28
Construct for LOINC Short Name
Parathyrin.1-84

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP268392-0

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Parathormona 1-84
it-IT Italian (Italy) Paratirina.1-84
zh-CN Chinese (China) 甲状旁腺素.1-84
Synonyms: PTH.1-84
el-GR Greek (Greece) Παραθορμόνη.1:-84
Synonyms: Παραθορμόνη.1:-84