LP28537-6
Tau protein
Active
Descriptions
CSF tau phosphorylated at threonine 181 (p-tau181) is a widely used biomarker for Alzheimer disease (AD) and has recently been regarded to reflect β-amyloid and/or p-tau deposition in the AD brain. Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease characterized by intranuclear inclusions in neurons, glial cells, and other somatic cells. Symptoms include dementia, neuropathy, and others. CSF biomarkers were not reported. The objective of this study was to investigate whether CSF biomarkers including p-tau181 are altered in patients with NIID. Source: Máxima MC,
Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease.
Tau proteins interact with tubulin to stabilize microtubules and promote tubulin assembly into microtubules. Tau has two ways of controlling microtubule stability: isoforms and phosphorylation.
Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains. The isoforms are a result of alternative splicing in exons 2,3, and 10 of the tau gene.
Phosphorylation of tau is regulated by a host of kinases. For example, PKN, a serine/threonine kinase. When PKN is activated, it phosphorylates tau, resulting in disruption of microtubule organization Taniguchi et al., 2001.
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Source: Wikipedia, Tau protein
Basic Part Properties
- Part Display Name
- Tau protein
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2001-08-31
- Construct for LOINC Short Name
- Tau Prot
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | Tau 蛋白 Synonyms: Alzheimer 病; |
| fr-CA | French (Canada) | Protéine Tau |
| et-EE | Estonian (Estonia) | Tau valk |
| es-ES | Spanish (Spain) | Proteína Tau |
| it-IT | Italian (Italy) | Tau, proteina Synonyms: Proteina Tau |
| tr-TR | Turkish (Turkey) | Tau protein |
| ru-RU | Russian (Russian Federation) | Тау протеин Synonyms: Тау белок |
| nl-NL | Dutch (Netherlands) | tau-proteïne |
| fr-BE | French (Belgium) | Protéine Tau |
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