LP30823-6
Amyloid beta 42 peptide
Active
Descriptions
Abeta 42 level is elevated in individuals whose chromosomes carry the genetic mutations characteristic of the early form of Alzheimer's. Source: Regenstrief Institute
Amyloid B-Protein is a peptide that ranges in size from 28-43 amino acids. Most fragments have the same biological activity as the whole molecule. Amyloid B-Protein causes vascular and cerebral plaque formation. Insoluble fibrils of Amyloid B-Protein accumulate in adrenal blood vessels and un neutritic plaques. Occurrence of plaques are present in normal brain but in a much less dense degree as in Alzheimer's disease patients. Amyloid B-Protein is also found in elevated levels in patients with Down's Syndrome. Substance P has been found to counteract the effects of Amyloid B-Protein. Source: Inter Science Institute, Inter Science Institute
Amyloid beta (Aβ or Abeta) is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. While it is most commonly known in association with Alzheimer's disease, it does not exist specifically to cause disease. Evidence has been found that Aβ has multiple non-disease activities.
The most common isoforms are Aβ40 and Aβ42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The Aβ40 form is the more common of the two, but Aβ42 is the more fibrillogenic and is thus associated with disease states. Mutations in APP associated with early-onset Alzheimer's have been noted to increase the relative production of Aβ42, and thus one suggested avenue of Alzheimer's therapy involves modulating the activity of β and γ secretases to produce mainly Aβ40.
Increases in either total Aβ levels or the relative concentration of both Aβ40 and Aβ42 (where the former is more concentrated in cerebrovascular plaques and the latter in neuritic plaques) have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease. Due to its more hydrophobic nature, the Aβ42 is the most amyloidogenic form of the peptide.
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Source: Wikipedia, Wikipedia
Basic Part Properties
- Part Display Name
- Amyloid beta 42 peptide
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2002-11-11
- Construct for LOINC Short Name
- AL beta42
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 淀粉样蛋白 Beta 42 肽 Synonyms: Ab42 peptide; |
| fr-CA | French (Canada) | Peptide amyloïde bêta 42 |
| es-ES | Spanish (Spain) | Péptido beta amiloide 42 |
| it-IT | Italian (Italy) | Amiloide beta 42 peptide |
| tr-TR | Turkish (Turkey) | Amiloid beta 42 peptid |
| ru-RU | Russian (Russian Federation) | Амилоид бета 42 пептид |
| nl-NL | Dutch (Netherlands) | amyloïd-bèta-42-peptide Synonyms: amyloid beta 42 peptide |
| fr-BE | French (Belgium) | Peptide amyloïde béta 42 |
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