LP32949-7
Lymphocyte proliferation
Active
Description
Ojo-Amaize, EA Lymphocyte Mitogen Stimulation. Lymphocyte mitogen stimulation assays are used for in vitro assessment of cellular immunity in patients with immunodeficiency, autoimmunity, infectious diseases, cancer and chemical-induced hypersensitivity reactions. Lymphocytes from healthy human subjects have receptors for mitogens such as the plant lectin concanavalin A (UCon A), pokeweed mitogen (PWM), the protein A component of Staphylococcus aureus Cowan strain I (SpA) and chemicals. Lymphocytes respond to these mitogens (substances that stimulate large numbers of lymphocytes without prior sensitization and in contrast to antigens do not require a sensitized host). Both B cells and T cells can be stimulated with mitogens. Inability of lymphocytes to respond to mitogens is a sign of impaired cell-mediated or humoral immunity.
There is a good correlation between CD4+ T-cell subset numbers and mitogenic response to PWM at different disease states in patients with HIV infection. [3H]-thymidine uptake is the gold standard for measuring lymphocyte mitogen stimulation.
However, a newer and more practical method utilizing supravital stains shows a good correlation with [3H]-thymidine uptake. Flow cytometry was also recently applied to analyze proliferation of cultured cells in response to stimulation with mitogen.
Copyright Copyright © 1996 - 2008 Specialty Laboratories
Source: Specialty Laboratories, Lymphocyte proliferation
Basic Part Properties
- Part Name
- Lymphocyte proliferation
- Part Display Name
- Lymphocyte proliferation
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2003-11-14
- Construct for LOINC Short Name
- Lymphocyte prolif
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 淋巴细胞增殖 |
| fr-CA | French (Canada) | Prolifération des lymphocytes |
| et-EE | Estonian (Estonia) | Lümfotsüütide proliferatsioon |
| es-ES | Spanish (Spain) | Proliferación de linfocitos |
| it-IT | Italian (Italy) | Linfociti, proliferazione Synonyms: Proliferazione dei linfociti |
| tr-TR | Turkish (Turkey) | Lenfosit proliferasyonu |
| ru-RU | Russian (Russian Federation) | Лимфоцит пролиферация |
| nl-NL | Dutch (Netherlands) | lymfocytenproliferatie |
| fr-BE | French (Belgium) | Prolifération des lymphocytes |
| pl-PL | Polish (Poland) | Proliferacja limfocytu Synonyms: Proliferacja limfocytu |
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