Version 2.77

Description

DNA index (DI), which is associated with DNA ploidy, is a reflection of the average amount of DNA in the tumor cells. The DI can be measured by flow cytometry or image cytometry, both of which result in a DNA ploidy histogram, where the channel number on the x-axis represents fluorescent intensity or optical density for the two methods, respectively. All cells with the same quantity of DNA form one peak on the histogram, and with a population of normal cells, the largest peak represents diploid cells in G1 of the cell cycle, and a smaller peak represents cells in G2/M-phase. When there is a mixed population of normal and tumor cells, two or more G1 peaks will be seen, one for the normal cells and one or more for the tumor cells. The DI is calculated by dividing the channel number of the tumor cell G1 peak by the channel number of the normal (diploid control) G1 peak. If the tumor cells are diploid, the DI is 1, and if the cells are aneuploid, the DI is greater than or less than 1. For example, tetraploid cells have a DI of 2 because they have twice as much DNA content as normal diploid cells, and hypodiploid tumor cells have a DI of <1. PMID: 24532190 Source: Regenstrief LOINC, PMID: 24532190

Basic Part Properties

Part Display Name
Monotypic plasma cell DNA ploidy
Part Type
Component (Describes the core component or analyte measured)
Created On
2019-07-01
Construct for LOINC Short Name
Monotypic PC DNA ploidy

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP410825-6

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 单型浆细胞 DNA 倍性
Synonyms: 单型（单一型）浆细胞 DNA 倍性
it-IT Italian (Italy) Plasmacellule monotipiche, ploidia DNA
Synonyms: Ploidia DNA delle plasmacellule monotipiche
es-ES Spanish (Spain) Ploidía de ADN de células plasmáticas monotípicas