LP66701-1
Ganglioside
Active
Description
Ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (AKA n-acetylneuraminic acid, NANA) linked on the sugar chain. The 60+ known gangliosides differ mainly in the position and number of NANA residues.
It is a component of the cell plasma membrane that modulates cell signal transduction events. It appears that they concentrate in lipid rafts.
They have recently been found to be highly important in immunology. Natural and semisynthetic gangliosides are considered possible therapeutics for neurodegenerative disorders.
Gangliosides are more complex glycosphingolipids in which oligosaccharide chains containing N-acetylneuraminic acid (NeuNAc) are attached to a ceramide. NeuNAc, an acetylated derivative of the carbohydrate sialic acid, makes the head groups of Gangliosides anionic. NB: the M in GM2 stands for monosialo, i.e., one NeuNAc residue. GM2 is the second monosialo ganglioside characterized, thus the subscript 2. Their structural diversity results from variation in the composition and sequence of the sugar residues. In all Gangliosides, the ceramide is linked through its C-1 to a β-glucosyl residue, which, in turn, is bound to a β-galactosyl residue.
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Source: Wikipedia, Wikipedia
Basic Part Properties
- Part Name
- Ganglioside
- Part Display Name
- Ganglioside
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2008-02-12
- Construct for LOINC Short Name
- Ganglioside
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 神经节苷脂 Synonyms: 神经节糖苷 |
| fr-CA | French (Canada) | Ganglioside |
| et-EE | Estonian (Estonia) | Gangliosiid |
| es-ES | Spanish (Spain) | Gangliósido |
| it-IT | Italian (Italy) | Ganglioside |
| tr-TR | Turkish (Turkey) | Gangliozid |
| ru-RU | Russian (Russian Federation) | Ганглиозид |
| nl-NL | Dutch (Netherlands) | ganglioside |
| fr-BE | French (Belgium) | Ganglioside |
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