LP97107-4
CYP2C19 gene
Active
Description
The CYP2C19 gene (cytochrome P450, family 2, subfamily C, polypeptide 19) [HGNC Gene ID:2621] is located on chromosome 10q24. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008] [NCBI Gene ID:1557] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Display Name
- CYP2C19 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2009-09-18
- Construct for LOINC Short Name
- CYP2C19
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | CYP2C19 基因 Synonyms: Cytochrome P450, family 2, subfamily C, polypeptide 19; |
| et-EE | Estonian (Estonia) | CYP2C19 geen |
| es-ES | Spanish (Spain) | Gen CYP2C19 |
| it-IT | Italian (Italy) | CYP2C19, gene Synonyms: Gene CYP2C19 |
| tr-TR | Turkish (Turkey) | CYP2C19 geni |
| ru-RU | Russian (Russian Federation) | CYP2C19 ген |
| nl-NL | Dutch (Netherlands) | CYP2C19-gen Synonyms: CYP2C19 gen |
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