LP97520-8
5-Alpha tetrahydrocortisol
Active
Description
5 alpha-Tetrahydrocortisol is a normal human metabolite. However its increased ratio (5alpha-Tetrahydrocortisol + Tetrahydrocortisol) over Tetrahydrocortisone in urine is the biochemical marker for the syndrome of apparent mineralocorticoid excess (AME). AME is a heritable form of hypertension due to an inborn error of cortisol metabolism and is characterized by hypokalemia and low renin levels despite subnormal or normal levels of aldosterone and other known mineralocorticoids. The syndrome is attributable to congenital deficiency of the enzyme 11 beta-hydroxydehydrogenase (11 beta-HSD), which converts cortisol to biologically inactive cortisone. This results in a prolonged half-life of Cortisol, which acts at the kidney level as a potent mineralocorticoid. PMID: 8732999 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, 5-Alpha tetrahydrocortisol
Basic Part Properties
- Part Display Name
- 5-Alpha tetrahydrocortisol
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2009-10-08
- Construct for LOINC Short Name
- 5-A THF
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 5-Alpha 四氢皮质醇 Synonyms: 5-A 四氢皮质醇; |
| fr-CA | French (Canada) | 5-alpha tétrahydrocortisol |
| et-EE | Estonian (Estonia) | 5-alfatetrahüdrokortisool |
| es-ES | Spanish (Spain) | 5-Alfa tetrahidrocortisol |
| it-IT | Italian (Italy) | 5-Alfa tetraidrocortisolo |
| tr-TR | Turkish (Turkey) | 5-Alfa tetrahidrokortizol |
| ru-RU | Russian (Russian Federation) | 5-Альфа тетрагидрокортизол |
| nl-NL | Dutch (Netherlands) | 5-alfa-tetrahydrocortisol |
| fr-BE | French (Belgium) | 5-Alpha tétrahydrocortisol |
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