Version 2.78

Part Description

LP32458-9   von Willebrand factor cleaving protease
von Willebrand factor (vWF) cleaving protease, or ADAMTS13, is a metalloprotease that cleaves vWF and thereby limits platelet aggregation and formation of microthrombi. vWF cleaving protease inhibitors can decrease the protease activity and/or more rapidly remove the enzyme from the circulation. Such inhibitors are one cause of thrombotic thrombocytopenic purpura (TTP), a disorder characterized by thrombocytopenia, anemia, fever, and neurologic and renal abnormalities. Idiopathic TTP is often due to anti-ADAMTS13 autoantibodies, while inherited TTP is an autosomal recessive disorder due to mutations in the ADAMTS13 gene that lead to impaired protease function. Work-up of patients with TTP can include vWF cleaving protease activity and, if that activity is low, inhibitor screen followed by quantification. PMID: 18756543 Source: Regenstrief LOINC

Fully-Specified Name

Component
von Willebrand factor cleaving protease
Property
PrThr
Time
Pt
System
PPP
Scale
Ord
Method

Additional Names

Short Name
vWF Cp PPP Ql
Display Name
vWf cleaving protease Ql (PPP)
Consumer Name Alpha Get Info
vWf cleaving protease, Blood

Example Answer List: LL2354-0

Source: Regenstrief LOINC
Answer Code Score Answer ID
NormalCopyright http://snomed.info/sct ID:17621005 Normal (qualifier value) LA6626-1
AbnormalCopyright http://snomed.info/sct ID:263654008 Abnormal (qualifier value) LA12748-2

Basic Attributes

Class
COAG
Type
Laboratory
First Released
Version 2.10
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
14218

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: ADAMTS-13 Aktivität
de-DE German (Germany) von Willebrand-Faktor spaltende Protease:Nachweis oder Schwellenwert:Zeitpunkt:Thrombozytenarmes Plasma:Ordinal:
es-AR Spanish (Argentina) proteasa desdobladora del factor de von Willebrand:concentración arbitraria:punto en el tiempo:plasma desplaquetado:ordinal:
es-ES Spanish (Spain) Proteasa divisora del Factor de von Willebrand:PrThr:Punto temporal:Plasma pobre en plaquetas:Ord:
es-MX Spanish (Mexico) proteasa de escisión del factor von Willebrand:Presencia o umbral:Punto temporal:Plasma pobre en plaquetas:Ordinal:
fr-CA French (Canada) Protéase clivage du Facteur von Willebrand:Présence-Seuil:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:
fr-FR French (France) Facteur Willebrand protéase:Présence/Seuil:Ponctuel:Plasma pauvre en plaquettes:Qualitatif:
fr-BE French (Belgium) Protéase de clivage du Facteur von Willebrand:PrThr:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:
Synonyms: Fvw
it-IT Italian (Italy) von Willebrand, proteasi di taglio fattore:PrThr:Pt:PPP:Ord:
Synonyms: Fattore di von Willebrand (vWf) Plasma povero di piastrine Presenza o Soglia Proteasi di taglio del fattore di von Willebrand Punto nel tempo (episodio) Studio di coagulazione
ko-KR Korean (Korea, Republic Of) 폰 빌레브란트 인자 절단 단백분해효소:임의농도:검사시점:혈소판제거혈장:순위척도:
nl-NL Dutch (Netherlands) von Willebrand-factor cleaving protease:aanwezigheid:moment:plaatjesarm plasma:ordinaal:
Synonyms: coagulatiemethode
pt-BR Portuguese (Brazil) fator de von Willebrand clivagem da protease:ACnc:Pt:PPPQ:Ord:
Synonyms: ; vWF Cp; ADAMTS13; vWCP; VWF-cp; VWFCP; vWf; Arbitrary concentration; Point in time; Random; Platelet poor plasma; Plas; Ql; Ordinal; QL; Qualitative; Qual; Screen; Vonwillebrand; Von will; PR; Fac; Fact; COAGULATION
ru-RU Russian (Russian Federation) von Willebrand фактор (vWf) расщепляющая протеаза:PrThr:ТчкВрм:ОПП:Пор:
Synonyms: Обеднённая пластинками плазма;Бедная тромбоцитами плазма Порядковый Точка во времени;Момент
tr-TR Turkish (Turkey) von Willebrand faktörü parçalıyıcı proteaz:MevcEşik:Zmlı:TFkP:Srl:
Synonyms: Mevcut
zh-CN Chinese (China) von Willebrand 因子裂解蛋白酶:存在情况或阈值:时间点:贫血小板血浆:序数型:
Synonyms: von Willebrand von Willebrand 因子（von Willebrand Factor，vWf）;vWf;vWf 因子;血管性假血友病因子;血管性血友病因子 von Willebrand 因子（vWf 因子、血管性假血友病因子、血管性血友病因子）裂解蛋白酶;ADAMTS13;von Willebrand 因子裂解蛋白酶（von Willebrand Factor Cleaving Protease，VWF-cp）;von Willebrand 因子裂解酶;vWCP;vWf 因子裂解蛋白酶;vWf 因子裂解酶;vWf 裂解酶;VWFCP;VWF-cp;血管性血友病因子裂解蛋白酶;血管性血友病因子裂解酶 乏血小板血浆;Platelet poor plasma;PPP 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 冯·威勒布兰德 冯威勒布兰德 冯威勒布兰德氏 凝血功能;凝血功能试验;凝血过程;血液凝固;血液凝固功能;血液凝固过程 因素 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 朊酶 系数 蛋白质酵素

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=34589-2