Version 2.78

Part Descriptions

LP28537-6   Tau protein
CSF tau phosphorylated at threonine 181 (p-tau181) is a widely used biomarker for Alzheimer disease (AD) and has recently been regarded to reflect β-amyloid and/or p-tau deposition in the AD brain. Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease characterized by intranuclear inclusions in neurons, glial cells, and other somatic cells. Symptoms include dementia, neuropathy, and others. CSF biomarkers were not reported. The objective of this study was to investigate whether CSF biomarkers including p-tau181 are altered in patients with NIID. Source: Máxima MC,

LP28537-6   Tau protein
Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease.

Tau proteins interact with tubulin to stabilize microtubules and promote tubulin assembly into microtubules. Tau has two ways of controlling microtubule stability: isoforms and phosphorylation.

Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains. The isoforms are a result of alternative splicing in exons 2,3, and 10 of the tau gene.

Phosphorylation of tau is regulated by a host of kinases. For example, PKN, a serine/threonine kinase. When PKN is activated, it phosphorylates tau, resulting in disruption of microtubule organization Taniguchi et al., 2001. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Tau protein

Fully-Specified Name

Component
Tau protein/Amyloid beta 42 peptide
Property
Ratio
Time
Pt
System
CSF
Scale
Qn
Method

Additional Names

Short Name
Tau Prot/AL beta42 CSF-Rto
Display Name
Tau protein/Amyloid beta 42 peptide (CSF) [Ratio]
Consumer Name Alpha Get Info
Tau protein/Amyloid Beta 42 Peptide, Spinal fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.15
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
14186

Member of these Panels

LOINC Long Common Name
104134-2 Dementia evaluation panel - Cerebral spinal fluid

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Tau/Amyloid Beta 42 Ratio /Liquor
es-ES Spanish (Spain) Proteína Tau/Péptido beta amiloide 42:Fracción:Punto temporal:Líquido Cefalorraquideo:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Proteína tau / péptido beta amiloide 42:Proporción:Punto temporal:Fluído espinal cerebral:Cuantitativo:
fr-CA French (Canada) Protéine Tau/Peptide amyloïde bêta 42:Ratios:Temps ponctuel:LCR:Quantitatif:
fr-FR French (France) Protéines Tau/peptide bêta amyloïde 1-42:Ratio:Ponctuel:Liquide céphalorachidien:Numérique:
fr-BE French (Belgium) Protéine Tau/Peptide amyloïde béta 42:Ratios:Temps ponctuel:LCR:Quantitatif:
it-IT Italian (Italy) Tau, proteina/Amiloide beta 42 peptide:Rapporto:Pt:LCS:Qn:
Synonyms: Chimica Liquido cerebrospinale Proteina Tau Punto nel tempo (episodio)
ko-KR Korean (Korea, Republic Of) 타우 단백/아밀로이드 베타 42 펩티드:비율:검사시점:뇌척수액:정량:
nl-NL Dutch (Netherlands) tau-proteïne/amyloïd-bèta-42-peptide:verhouding:moment:liquor cerebrospinalis:kwantitatief:
Synonyms: amyloid beta 42 peptide
pt-BR Portuguese (Brazil) Proteína tau/Beta amilóide peptídeo 42:Ratio:Pt:LCR:Qn:
Synonyms: ; Tau Prot; Alzheimer disease; PR; AL beta42; Aceta 42; Beta-amyloid; Ac42 peptide; Rto; Point in time; Random; Cerebral spinal fluid; Spinal Fluid; Cerebrospinal Fl; Spinal Flu; Spinal Fld; Quantitative; QNT; Quant; Quan; Pept; B; Chemistry
ru-RU Russian (Russian Federation) Тау протеин/Амилоид бета 42 пептид:Отношение:ТчкВрм:ЦСЖ:Колич:
Synonyms: Белок Количественный Коэффициент;Соотношение;Пропорция Тау белок Точка во времени;Момент Цереброспинальная жидкость
tr-TR Turkish (Turkey) Tau protein/Amiloid beta 42 peptid:Oran:Zmlı:BOS:Kant:
zh-CN Chinese (China) Tau 蛋白/淀粉样蛋白 Beta 42 肽:比率:时间点:脑脊液:定量型:
Synonyms: Ab42 peptide;Ab42 肽;Abeta 42;AL beta42;Alzheimer 氏病;Alzheimer 病;Alzheimer氏病;Alzheimer病;Beta 淀粉样肽;Beta-淀粉样肽;Beta-淀粉样蛋白;Beta-淀粉状朊;Beta-淀粉状蛋白;β淀粉样肽;β-淀粉样肽;β-淀粉样蛋白;β-淀粉状朊;β-淀粉状蛋白;淀粉状蛋白 Beta 42 肽;淀粉样蛋白β42 肽;淀粉状朊 Beta 42 肽;淀粉状朊β42 肽;淀粉状蛋白β42 肽;老年性痴呆;老年痴呆;阿尔茨海默病 Ab42 肽;淀粉状蛋白 Beta 42 肽 Alzheimer 病;蛋白 Tau;阿尔茨海默病 B CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 β 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 来自于不同体系的两个观察指标之比;比;比值 淀粉样蛋白 淀粉状朊 硫酸胶化纤维素 类淀粉物 缩氨酸 胶化纤维素 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 贝塔

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=41027-4