76413-4
Sheep prion protein codon 112 [Type] in Blood by Genotype method
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Part Description
LP188416-4 Sheep prion protein codon 112
Scrapie is a fatal, degenerative disease affecting the central nervous system of sheep and goats. It is in the same class of diseases as BSE in cattle and Chronic Wasting Disease in elk and deer. Transmission of the classical scrapie agent is not completely understood but apparently healthy sheep infected with the agent can transmit disease. Sheep and goats are typically infected as young lambs or kids, though adult sheep and goats can become infected. The infecting agent or prion is a mal-formed version (PrPsc ) of a normal protein (PrP) found in all animals. The malformation of the normal prion proteins occurs when they are exposed to the mal-formed version of the protein. The normal prion proteins may be more or less susceptible to malformation when they are exposed to the mal-formed protein based on their genetic makeup. Resistance or susceptibility has been linked to the presence of certain amino acids at various locations within the normal protein. Genotyping determines the amino acids present at specific locations or codons in the prion protein. These are reported as a pair of one character amino acid codes such as RR, RH, QQ, etc. This testing does not diagnosis Scrapie, but is an important tool for selecting genetically resistant animals for breeding and eradication. Codons associated with susceptibility/resistance to scrapie include codon 112, 136, 141, 154 and 171. Codon 112 codes for either methionine (M) or threonine (T). The presence of T at codon 112 has been associated with increased resistance to scrapie.
Source: American Association of Veterinary Laboratory Diagnosticians
Fully-Specified Name
- Component
- Sheep prion protein codon 112
- Property
- Type
- Time
- Pt
- System
- Bld
- Scale
- Nom
- Method
- Genotyping
Additional Names
- Long Common Name
- Sheep prion protein codon 112 [Type] in Blood by Genotype method
- Short Name
- Sheep PrP codon 112 Bld Genotyp
- Display Name
- Sheep prion protein codon 112 Genotyping Nom (Bld)
- Consumer Name Alpha Get Info
- Sheep prion protein codon 112, Blood
Example Answer List: LL3173-3
Source: American Association of Veterinary Laboratory Diagnosticians| Answer | Code | Score | Answer ID |
|---|---|---|---|
| TT | LA21963-6 | ||
| TM | LA21964-4 | ||
| MM | LA21965-1 |
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.52
- Last Updated
- Version 2.52
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | proteína priónica en oveja, codon 112: |
| es-MX | Spanish (Mexico) | Codón 112 de proteína priónica de oveja: |
| it-IT | Italian (Italy) | Pecora, proteina prionica codone 112: Synonyms: Patologia molecolare Punto nel tempo (episodio) Sangue Suscettibilità al genotipo virale |
| nl-NL | Dutch (Netherlands) | schapen prionproteïne codon 112: |
| pl-PL | Polish (Poland) | Białko prionowe owcy kodon 112: |
| tr-TR | Turkish (Turkey) | Koyun prion proteini kodon 112: Synonyms: Tür |
| zh-CN | Chinese (China) | 绵羊朊蛋白密码子 112: Synonyms: PR; |
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