79722-5
SLCO1B1 gene product functional interpretation in Blood or Tissue Qualitative by Molecular genetics method
Active
Term Description
The SLCO1B1 gene product functional interpretation is determined by the reporting lab and returned with the structured test results. The Preferred Answer list associated with this term is based on the Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for reporting SLCO1B1 gene product functional activity (phenotype). This specific interpretation would be considered a separate observation made by the lab in addition to the primary reported results (e.g., genotype) and it could be included with other assay-specific observations, which would ideally support the interpretation value.[https://cpicpgx.org/resources.html]
Source: Regenstrief LOINC
Part Description
LP202928-0 SLCO1B1 gene product functional interpretation
Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene [HGNC Gene ID: 2645]. Variations in the SLCO1B1 gene have been significantly associated with a marked increase in systemic exposure to simvastatin and risk of muscle toxicity. PMID: 24918167 The overall effect size and significance of this association are striking for simvastatin compared to other statins. Patients with variations in SLCO1B1 (a transporter of simvastatin) may require a lower simvastatin dose or an alternative statin as compared to patients who do not have this variant. See https://www.pharmgkb.org/gene/PA134865839 for more information and dosing guidelines for drugs impacted by SLCO1B1 genetic variation.
Source: Clinical Pharmacogenetics Implementation Consortium
Fully-Specified Name
- Component
- SLCO1B1 gene product functional interpretation
- Property
- Imp
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Ord
- Method
- Molgen
Additional Names
- Short Name
- SLCO1B1 gene prod funct imp Bld/T
- Display Name
- SLCO1B1 gene product functional interpretation Molgen Ql (Bld/Tiss) [Interp]
- Consumer Name Alpha Get Info
- SLCO1B1 gene product Functional interpretation, Blood or tissue specimen
Preferred Answer List: LL3858-9
Source: Clinical Pharmacogenetics Implementation Consortium| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Increased function | LA25392-4 | ||
| Normal function | LA25393-2 | ||
| Decreased function | LA25395-7 | ||
| Poor function | LA25394-0 |
Basic Attributes
- Class
- MOLPATH.PHARMG
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.67
- Order vs. Observation
- Observation
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-AT | German (Austria) | Synonyms: SLCO1B1-Genotypisierung |
| es-ES | Spanish (Spain) | Gen SLCO1B1 interpretación de la función del fármaco: |
| es-MX | Spanish (Mexico) | Interpretación funcional del producto del gen SLCO1B1: |
| fr-FR | French (France) | SLCO1B1 gène fonctionnement du produit génétique interprétation: |
| it-IT | Italian (Italy) | Interpretazione funzionale del gene SLCO1B1: Synonyms: Farmacogenomica Gene SLCO1B1 Genetica molecolare Impressione/interpretazione di studio Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | SLCO1B1-gen product functionele interpretatie: Synonyms: molgen SLCO1B1 gen product functionele interpretatie |
| tr-TR | Turkish (Turkey) | SLCO1B1 geni ürünü fonksiyonu yorumu: |
| zh-CN | Chinese (China) | SLCO1B1 基因产物功能解释: Synonyms: SLCO1B1 基因产物功能（功能性、 |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=79722-5
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