Version 2.78

Term Description

An interpretation of "resistance predicted" suggests that treatment failure with sofosbuvir may be due to the presence of an NS5B mutation (S282T). An interpretation of "resistance not predicted" indicates that the S282T sofosbuvir resistance mutation was not detected.
Source: Regenstrief LOINC

Part Description

LP220265-5   Sofosbuvir
Sofosbuvir (Sovaldi) is a nucleotide analogue NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection as a component of a combination antiviral treatment regimen. The replication of HCV requires NS5B, an RNA-dependent RNA polymerase, responsible for the synthesis of both positive-strand genomic RNA and negative-strand RNA. Sofosbuvir mimics the natural substrate of NS5B polymerase and becomes incorporated into the growing RNA, inducing a chain termination event. Sofosbuvir, as one of the nucleos(t)ide analog inhibitors, has a distinct resistance profile that does not overlap with the non-nucleoside NS5B protease inhibitors. Resistance to sofosbuvir is uncommon. The S282T mutation has been identified as the common variant to pose resistance to sofosbuvir, however, this variant is not generally found in untreated patients with HCV. PMID: 24883006 Source: Regenstrief LOINC

Fully-Specified Name

Component
Sofosbuvir
Property
Susc
Time
Pt
System
Isolate
Scale
Ord
Method
Genotyping

Additional Names

Short Name
Sofosbuvir Islt Genotyp
Display Name
Sofosbuvir Genotyping [Susc]
Consumer Name Alpha Get Info
Susceptibility to Sofosbuvir

Example Answer List: LL4039-5

Source: Quest Diagnostics Inc.
Answer Code Score Answer ID
Resistance predicted LA26373-3
Resistance not predicted LA26374-1

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
15627

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Sofosbuvir:Susceptibilidad:Punto temporal:Aislado:Ord:Susceptibilidad al genotipo viral
es-MX Spanish (Mexico) Sofosbuvir:Susceptibilidad (microorganismos):Punto temporal:Aislado:Ordinal:Susceptibilidad del genotipo viral
fr-FR French (France) Sofosbuvir:Sensibilité:Ponctuel:Isolat:Qualitatif:Génotypage
it-IT Italian (Italy) Sofosbuvir:Susc:Pt:Isolato:Ord:Genotipizzazione
Synonyms: Punto nel tempo (episodio) Sensibilità (microrganismi) Suscettibilità agli antibiotici Suscettibilità al genotipo virale
nl-NL Dutch (Netherlands) sofosbuvir:gevoeligheid:moment:isolaat:ordinaal:genotypering
zh-CN Chinese (China) 索非布韦:抗生素敏感性:时间点:分离株:序数型:基因分型
Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分离物;分离菌;分离菌株;隔离种群 基因型分型;基因型分析;基因型定型;基因定型;病毒基因型敏感性试验 抗生素敏感性(微生物);敏感性;某种抗微生物制剂对于某个分离株的影响;药物敏感性;药物敏感性(微生物) 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 时刻;随机;随意;瞬间 索氟布韦;Sovaldi;丙型肝炎病毒(HCV)核苷酸类似物NS5B聚合酶抑制剂;CAS 1190307-88-0;C22H29FN3O9P;EINECS 20150104

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82382-3