86509-7

Varicella zoster virus clade [Type] in Specimen by Molecular genetics method

Active

Term Description

This term is created for a test that involves amplification and sequencing of 3 open reading frames of VZV (ORF21, ORF22 and ORF50) to categorize strains into one of the 7 known clades of VZV.
Source: Regenstrief LOINC

Part Description

LP260859-6 Varicella zoster virus clade
Varicella zoster virus (VZV) is a double-stranded alphaherpesvirus that causes seasonal outbreaks of chickenpox and shingles in non-immunized populations. VZV is highly infectious and is transmitted by contact with the ruptured fluid filled blisters and respiratory secretions of infected individuals. Immunity post infection is usually lifelong though the latent virus inhabits the sensory nerve ganglia where it can reactivate causing shingles when immunity declines with aging.[http://jvi.asm.org/content/88/24/13936.full] In the over fifty strains of VZV that have been sequenced it has been found that a single nucleotide polymorphism occurs about every 100 bases. The patterns of polymorphisms in VZV correlate with different geographical regions of infection and is the basis for the classification of viral clades.[https://grose.lab.uiowa.edu/vzv-genomes-and-evolution] Breuer proposed the nomenclature for the VZV clades as 1-5 with the suspected clades VI and VII to be confirmed later. The geographical regions associated with the seven clades are as follows:
Clades 1 and 3-represent the dominant clades of the circulating VZV in Europe and the Americas
Clades 4 and 5-found in Africa
Clade VI found in France, Italy
Clade VII exclusively isolated in the US
Clade 2-Asia from Korea, Japan, China not found in India, Nepal and Bangladesh where clades 4 and 5 were dominant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054591/ Source: Regenstrief LOINC

Fully-Specified Name

Component: Varicella zoster virus clade
Property: Type
Time: Pt
System: XXX
Scale: Nom
Method: Molgen

Additional Names

Short Name: VZV clade Spec
Display Name: VZV clade Molgen Nom (Specimen)
Consumer Name Alpha Get Info: Varicella zoster virus clade, Specimen

Example Answer List: LL4417-3

Source: Regenstrief LOINC

Answer	Code	Score	Answer ID
Varicella-zoster virus clade 1			LA27282-5
Varicella-zoster virus clade 2			LA27283-3
Varicella-zoster virus clade 3			LA27285-8
Varicella-zoster virus clade 4			LA27286-6
Varicella-zoster virus clade 5			LA27287-4
Varicella-zoster virus clade VI			LA27288-2
Varicella-zoster virus clade VII			LA27289-0
Unable to type			LA27090-2
InconclusiveCopyright http://snomed.info/sct ID:419984006 Inconclusive (qualifier value)			LA9663-1
Test not doneCopyright http://snomed.info/sct ID:373121007 Test not done (qualifier value)			LA18373-3
Variable			LA18409-5

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.61
Last Updated: Version 2.69
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG32750-8	Varicella zoster virus

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	Varicella-Zoster-Virus-Klade:Typ:Zeitpunkt:XXX:Nominal:Molekulargenetisch
es-ES	Spanish (Spain)	Clados del virus de Varicela Zoster:Tipo:Punto temporal:XXX:Nom:Genética molecular
es-MX	Spanish (Mexico)	Clado del virus de la varicela zóster:Tipo:Punto temporal:XXX:Nominal:Genética molecular
fr-FR	French (France)	Varicelle zona virus clade:Type:Ponctuel:Milieux divers:Résultat nominal:Biologie moléculaire
it-IT	Italian (Italy)	Varicella zoster virus clade:Tipo:Pt:XXX:Nom:Molgen Synonyms: Genetica molecolare Microbiologia Punto nel tempo (episodio) Virus della varicella zoster
nl-NL	Dutch (Netherlands)	varicella-zostervirus clade:type:moment:XXX:nominaal:moleculair genetisch onderzoek Synonyms: molgen Varicella zoster virus Varicella zoster virus clade
zh-CN	Chinese (China)	水痘带状疱疹病毒进化枝:类型:时间点:XXX:名义型:分子遗传学类实验室方法 Synonyms: HHV-3;VZ;VZV;人类疱疹病毒 3 型;人类疱疹病毒 III 型;带状疱疹;水痘;水痘带状疱疹;水痘病毒;Varicella zoster virus;水痘-带状疱疹病毒不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答型微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）时刻;随机;随意;瞬间水痘带状疱疹病毒（HHV-3、VZV、人类疱疹病毒 3 型、疱疹病毒 III 型、带状疱疹病毒、水痘-带状疱疹病毒）进化枝（分支、支、支系、分枝、分化体、种系分枝、演化支）

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=86509-7

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

LOINC Copyright

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.