Version 2.80

Part Description

LP248780-1   Thymidine synthase activity interpretation
Thymidine synthase is the enzyme that catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) using the methyl donor 5,10-methylenetetrahydrofolate (CH2THF) as a cofactor. dTMP is critical for DNA repair and replication. Thymidine synthase has become the target for drugs used in the treatment of some cancers including the drug 5-fluorouracil (5-FU). The active metabolite of 5-FU combines with the nucleotide binding site of TS which prevents dUMP from being able to bind with TS. The decreased amount of dUMP leads to decreased cell replication. Studies have shown that the gene amplification of TS in the tumor cells correlate to resistance to 5-FU. http://www.nature.com/nrc/journal/v3/n5/fig_tab/nrc1074_F2.html Source: Regenstrief LOINC

Fully-Specified Name

Component
Thymidine synthase activity interpretation
Property
Imp
Time
Pt
System
Bld/Tiss
Scale
Ord
Method

Additional Names

Long Common Name
Thymidine synthase activity interpretation in Blood or Tissue Qualitative
Short Name
TS act interp Bld/T-Imp
Display Name
Thymidine synthase activity interpretation Ql (Bld/Tiss) [Interp]
Consumer Name Alpha Get Info
Thymidine synthase activity interpretation, Blood or tissue specimen

Example Answer List: LL4462-9

Source: Regenstrief LOINC
Answer Code Score Answer ID
High LA9193-9
NormalCopyright http://snomed.info/sct ID:17621005 Normal (qualifier value) LA6626-1

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.63 (ADD)
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Ερμηνεία δραστηριότητας της συνθάσης της θυμιδίνης:Imp:Pt:Αίμα/Ιστός:Ord:
Synonyms: Imp Δραστηριότητα Ερμηνεία Ερμηνεία δραστηριότητας της συνθάσης της θυμιδίνης Θυμιδίνη
es-ES Spanish (Spain) Actividad timidina sintetasa, interpretación:Impresión/interpretación del estudio:Punto temporal:Sangre o tejido:Ord:
es-MX Spanish (Mexico) Interpretación de la actividad de la timidina sintasa:Impresión / interpretación del estudio:Punto temporal:Sangre o tejido:Ordinal:
fr-FR French (France) Thymidine synthase activité interprétation:Interprétation:Ponctuel:Sang/Tissu:Qualitatif:
it-IT Italian (Italy) Timidina, interpretazione dell'attività di sintesi:Imp:Pt:Sangue/Tess:Ord:
Synonyms: Farmacogenomica Impressione/interpretazione di studio Interpretazione dell''attività di sintesi della tim Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
zh-CN Chinese (China) 胸苷合成酶活性解释:印象:时间点:全血/组织:序数型:
Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 判读;解释说明;说明;释义;阐明 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 活动 胸腺嘧啶核苷;胸腺定;胸苷;脱氧胸苷 胸苷（胸腺嘧啶脱氧核苷）合成酶（合酶）活性解释（说明） 血;血液

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=87410-7