Version 2.79

Term Description

The percent of CD45+CD3- cells, which represent the major natural killer (NK)-cell subsets, relative to total NK cells (NK cell subsets) or total lymphocytes (NK T cells), depending on the clinical context, for the assessment of patients with HIV, primary immune deficiencies with NK cell defects, NK-cell lymphocytosis, solid-organ transplantation, immune reconstitution following bone marrow or hematopoietic cell transplantation, and evaluation of NK cells in neoplasias.

Part Description

LP266960-6   Cells.CD3-CD45+
Cells expressing CD45 (CD45+) in the absence of CD3 (CD3-) are used as an initial gating population for identifying natural killer (NK) cells. In addition to CD3-, a majority of NK cells are further gated on the expression of CD56 (neural cell adhesion molecule) and CD16 (low-affinity IgG Fc receptor-FcgammaRIII) cell surface markers. However, NK cells are not a homogeneous population since not all NK cells express the CD56 and CD16 markers uniformly. PMID: 17920947 NK cells that express CD56+ and are CD16- are called regulatory or cytokine secreting NK cells, whereas NK cells that express CD16+ and are CD56+/- (dim or negative) are referred to as cytotoxic NK cells. PMID: 19278419 NK cell deficiencies may be present in various primary (monogenic) immunodeficiencies (e.g.autoimmune lymphoproliferative syndrome (ALPS), familial hemophagocytic lymphohistiocytosis (FHL), Hermansky-Pudlak syndrome, Papillon-Lefevre syndrome, severe combined immunodeficiencies) or in isolated NK cell deficiency (e.g. absolute NK cell deficiency (ANKD), the classic NK cell deficiency (CNKD), and the functional NK cell deficiency (FNKD)). PMID: 17088643 Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.CD3-CD45+/Cells
Property
NFr
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Long Common Name
CD3-CD45+ cells/cells in Blood
Short Name
CD3-CD45+ cells NFr Bld
Display Name
CD3-CD45+ cells/cells (Bld)
Consumer Name Alpha Get Info
CD3-CD45+ cells/cells, Blood

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.79 (NAM)
Change Reason
Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component;
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
98073-0 Natural killer and natural killer T cell subsets panel - Blood
53759-7 Natural killer cell panel - Blood by Flow cytometry (FC)

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Κύτταρα.CD3-CD45+/κύτταρα:NFr:Pt:Αίμα:Qn:
Synonyms: CD3 CD45 NFr Κύτταρα Κύτταρα.CD3 Κύτταρα.CD3+CD45+ Κύτταρα.CD3-CD45+
es-ES Spanish (Spain) Células CD3-CD45+/células:Fracción numérica:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Células CD3-CD45 + / 100 células:Fracción numérica:Punto temporal:Sangre:Cuantitativo:
fr-FR French (France) CD3-CD45+/100 cellules:Fraction de nombres:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) Cellule.CD3-CD45+/cellule:NFr:Pt:Sangue:Qn:
Synonyms: Cellule CD3 Cellule CD3+CD45+ Cellule CD3-CD45+ Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
zh-CN Chinese (China) 细胞.CD3-CD45+/细胞:计数型分数:时间点:全血:定量型:
Synonyms: B220;CD45R;CD45RA;CD45RB;CD45RC;CD45RO;LCA;Ly5;T200;白细胞共同 Ag;白细胞共同分化 Ag;白细胞共同分化抗原;白细胞共同抗原 CD3+CD45+细胞 CD3细胞 Leu4;Leu-4;T3 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89311-5