Version 2.78

Term Description

The total concentration of CD45+ CD3- cells. Natural killer (NK) cell subsets (based on CD16+ and CD56+ expression) are derived from CD45+ CD3- cell gate, whereas natural killer T (NKT) cells are gated on CD45+ CD3+ cells.
Source: Regenstrief LOINC

Part Description

LP266960-6   Cells.CD3-CD45+
Cells expressing CD45 (CD45+) in the absence of CD3 (CD3-) are used as an initial gating population for identifying natural killer (NK) cells. In addition to CD3-, a majority of NK cells are further gated on the expression of CD56 (neural cell adhesion molecule) and CD16 (low-affinity IgG Fc receptor-FcgammaRIII) cell surface markers. However, NK cells are not a homogeneous population since not all NK cells express the CD56 and CD16 markers uniformly. PMID: 17920947 NK cells that express CD56+ and are CD16- are called regulatory or cytokine secreting NK cells, whereas NK cells that express CD16+ and are CD56+/- (dim or negative) are referred to as cytotoxic NK cells. PMID: 19278419 NK cell deficiencies may be present in various primary (monogenic) immunodeficiencies (e.g.autoimmune lymphoproliferative syndrome (ALPS), familial hemophagocytic lymphohistiocytosis (FHL), Hermansky-Pudlak syndrome, Papillon-Lefevre syndrome, severe combined immunodeficiencies) or in isolated NK cell deficiency (e.g. absolute NK cell deficiency (ANKD), the classic NK cell deficiency (CNKD), and the functional NK cell deficiency (FNKD)). PMID: 17088643 Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.CD3-CD45+
Property
NCnc
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Short Name
CD3-CD45+ cells # Bld
Display Name
CD3-CD45+ cells (Bld) [#/Vol]
Consumer Name Alpha Get Info
CD3-CD45+ cells, Blood

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
98073-0 Natural killer and natural killer T cell subsets panel - Blood
53759-7 Natural killer cell panel - Blood by Flow cytometry (FC)

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Células CD3-CD45+:Concentración de número:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Cells.CD3-CD45 +:Concentración numérica:Punto temporal:Sangre:Cuantitativo:
fr-FR French (France) CD3-CD45+:Nombre/Volume:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) Cellule.CD3-CD45+:NCnc:Pt:Sangue:Qn:
Synonyms: Cellule CD3 Cellule CD3+CD45+ Cellule CD3-CD45+ Concentrazione Numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
zh-CN Chinese (China) 细胞.CD3-CD45+:计数型浓度:时间点:全血:定量型:
Synonyms: B220;CD45R;CD45RA;CD45RB;CD45RC;CD45RO;LCA;Ly5;T200;白细胞共同 Ag;白细胞共同分化 Ag;白细胞共同分化抗原;白细胞共同抗原 CD3+CD45+细胞 CD3细胞 Leu4;Leu-4;T3 单位体积内的数量或计数;数量型浓度(单位体积);数量或计数型浓度(计数/体积);数量或计数型浓度(单位体积);计数型浓度(单位体积) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液

Example Units

Unit Source
{cells}/uL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89313-1