Version 2.80

Term Description

Parathyroid hormone is an 84 amino acid peptide designated PTH 1-84. Presence of the first six N-terminal amino acids ("N-terminus") is required for PTH biological activity, so assays that detect biologically active PTH have to, at a minimum, detect the N-terminus. This assay is different from intact parathyroid hormone assays, which are called intact because they detect the PTH molecule before it is degraded into C-terminal and N-terminal fragments by looking for the presence of segments in both the C- and N-terminal sides, but they do not necessarily detect the N-terminus.

Part Description

LP268392-0   Parathyrin.1-84
Parathyrin 1-84 (PTH (1-84)) is the biologically active hormone that regulates the calcium and phosphate levels in the circulation. PTH (1-84) is originally produced as a 118-amino acid polypeptide in the parathyroid glands. It is cleaved twice to form a functional 84-amino acid peptide that is stored in the parathyroid cells. The first 34 amino acids bind to the type 1 PTH/PTH-related peptide receptor that is expressed primarily in bone, kidney, cartilage, vessels, and certain developing organs. PMID: 26303600 The half-life of PTH (1-84) is 2-4 minutes, after which it is degraded into a carboxyl (C)- or amino (N)-terminal fragment. The C-fragments have a half-life of 5-10 minutes, are cleared by the kidneys, and can accumulate in the circulation during chronic kidney disease. Some evidence suggests that N-terminally truncated fragment PTH (7-84) may interact with receptors that regulate bone resorption and serum calcium concentrations that could lead to the quantification of other PTH fragments.[https://www.uptodate.com/contents/parathyroid-hormone-assays-and-their-clinical-use] Source: Regenstrief LOINC

Fully-Specified Name

Component
Parathyrin.1-84
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
IA

Additional Names

Long Common Name
Parathyrin.1-84 [Mass/volume] in Serum or Plasma by Immunoassay
Short Name
Parathyrin.1-84 SerPl IA-mCnc
Display Name
Parathyrin.1-84 IA [Mass/Vol]
Consumer Name Alpha Get Info
Parathyrin.1-84, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.65
Last Updated
Version 2.65 (ADD)
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG51038-4 Parathyrin.1-84|Pt|Ser/Plas|IA

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Παραθορμόνη.1:-84:MCnc:Pt:Ορός/Πλάσμα:Qn:IA
Synonyms: MCnc Παραθορμόνη.1:-84 Παραθυρίνη
es-ES Spanish (Spain) Parathormona 1-84:Concentración de masa:Punto temporal:Suero o Plasma:Qn:IA
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Paratirina 1-84:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
fr-FR French (France) Parathormone 1-84:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
it-IT Italian (Italy) Paratirina.1-84:MCnc:Pt:Siero/Plasma:Qn:IA
Synonyms: Chimica Concentrazione di Massa Immunoassay Paratormone Plasma Punto nel tempo (episodio) Siero Siero o Plasma
zh-CN Chinese (China) 甲状旁腺素.1-84:质量浓度:时间点:血清/血浆:定量型:免疫测定法
Synonyms: Ⅰ I PTH.1-84 PTH;甲状旁腺激素;甲旁素;甲旁;甲状旁腺激素（Parathyroid hormone，PTH） 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 血清或血浆

Example Units

Unit Source
pg/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=90741-0