Version 2.78

Part Descriptions

LP30823-6   Amyloid beta 42 peptide
Abeta 42 level is elevated in individuals whose chromosomes carry the genetic mutations characteristic of the early form of Alzheimer's. Source: Regenstrief Institute

LP30823-6   Amyloid beta 42 peptide
Amyloid beta (Aβ or Abeta) is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. While it is most commonly known in association with Alzheimer's disease, it does not exist specifically to cause disease. Evidence has been found that Aβ has multiple non-disease activities.

The most common isoforms are Aβ40 and Aβ42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The Aβ40 form is the more common of the two, but Aβ42 is the more fibrillogenic and is thus associated with disease states. Mutations in APP associated with early-onset Alzheimer's have been noted to increase the relative production of Aβ42, and thus one suggested avenue of Alzheimer's therapy involves modulating the activity of β and γ secretases to produce mainly Aβ40.

Increases in either total Aβ levels or the relative concentration of both Aβ40 and Aβ42 (where the former is more concentrated in cerebrovascular plaques and the latter in neuritic plaques) have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease. Due to its more hydrophobic nature, the Aβ42 is the most amyloidogenic form of the peptide. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component
Amyloid beta 42 peptide/Amyloid beta 40 peptide
Property
MRto
Time
Pt
System
CSF
Scale
Qn
Method

Additional Names

Long Common Name
Amyloid beta 42 peptide/Amyloid beta 40 peptide [Mass Ratio] in Cerebral spinal fluid
Short Name
AL beta42/ABeta 40 CSF
Display Name
Amyloid beta 42 peptide/Amyloid beta 40 peptide (CSF) [Mass ratio]
Consumer Name Alpha Get Info
Amyloid beta 42 peptide/Amyloid beta 40 peptide, Spinal fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.71
Last Updated
Version 2.74
Change Reason
Release 2.74: ORDER_OBS: Classified as both an order and an observation;
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
98492-2 Apolipoprotein E and beta amyloid Alzheimer's risk panel - Cerebral spinal fluid
106057-3 Beta-Amyloid 1-42 and 1-40 panel - Cerebral spinal fluid

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Amyloid Beta 42/Amyloid Beta 40 Ratio /L
es-ES Spanish (Spain) Péptido beta amiloide 42/Péptido amiloide beta 40 (Aβ40):Relacion de Masa:Punto temporal:Líquido Cefalorraquideo:Qn:
Synonyms: Cuantitativo
fr-FR French (France) Peptide bêta amyloïde 1-42/peptide bêta amyloïde 1-40:Masse ratio:Ponctuel:Liquide céphalorachidien:Numérique:
it-IT Italian (Italy) Amiloide beta 42 peptide/Amiloide beta 40 peptide:MRto:Pt:LCS:Qn:
Synonyms: Chimica Liquido cerebrospinale Punto nel tempo (episodio) Rapporto di Massa
nl-NL Dutch (Netherlands) amyloïd-bèta-42-peptide/amyloïd-bèta-40-peptide:massaverhouding:moment:liquor cerebrospinalis:kwantitatief:
Synonyms: amyloid beta 40 peptide amyloid beta 42 peptide
zh-CN Chinese (China) 淀粉样蛋白 Beta 42 肽/淀粉样蛋白 Beta 40 肽:质量比率:时间点:脑脊液:定量型:
Synonyms: Ab40 肽;淀粉状蛋白 Beta 40 肽 Ab42 peptide;Ab42 肽;Abeta 42;AL beta42;Alzheimer 氏病;Alzheimer 病;Alzheimer氏病;Alzheimer病;Beta 淀粉样肽;Beta-淀粉样肽;Beta-淀粉样蛋白;Beta-淀粉状朊;Beta-淀粉状蛋白;β淀粉样肽;β-淀粉样肽;β-淀粉样蛋白;β-淀粉状朊;β-淀粉状蛋白;淀粉状蛋白 Beta 42 肽;淀粉样蛋白β42 肽;淀粉状朊 Beta 42 肽;淀粉状朊β42 肽;淀粉状蛋白β42 肽;老年性痴呆;老年痴呆;阿尔茨海默病 B CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 β 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 来自于同一体系的两种分析物的质量之比;质量比 淀粉样蛋白 淀粉状朊 淀粉状蛋白 Beta 40 肽;Ab40 peptide;Ab40 肽;Abeta 40;AL beta40;Alzheimer 氏病;Alzheimer 病;Alzheimer氏病;Alzheimer病;Beta 淀粉样肽;Beta-淀粉样肽;Beta-淀粉样蛋白;Beta-淀粉状朊;Beta-淀粉状蛋白;β淀粉样肽;β-淀粉样肽;β-淀粉样蛋白;β-淀粉状朊;β-淀粉状蛋白;淀粉样蛋白β40 肽;淀粉状朊 Beta 40 肽;淀粉状朊β40 肽;淀粉状蛋白β40 肽;老年性痴呆;老年痴呆;阿尔茨海默病 硫酸胶化纤维素 类淀粉物 缩氨酸 胶化纤维素 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 贝塔

Example Units

Unit Source
pg/pg Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=98485-6