Version 2.78

Status Information

Status
DISCOURAGED
Comment
Recommend using the term with System Isolate/Specimen and Method Molgen that aligns with the new LOINC model for molecular resistance testing that was approved by Laboratory LOINC Committee in June 2018
Map-To Long Common Name Mapping Guidance
49617-4 Carbapenem resistance blaKPC gene [Presence] by Molecular method

Term Description

Qualitative detection of the nucleic acid sequences in the bacterial carbapenemase resistance blaKPC gene in positive blood culture specimens by target amplification and non-probe detection methods, such as melt curve analysis. This term was created for, but not limited in use to, the submitter's test kit, FilmArray Blood Culture Identification panel v2.
Source: Regenstrief LOINC

Part Descriptions

LP64707-0   Bacterial carbapenem resistance blaKPC gene
Non-susceptibility to carbapenems in gram-negative bacilli by means of the enzyme KPC (Klebsiella pneumoniae carbapenemase) is becoming more common. The gene beta-lactamase KPC (bla(KPC)) encodes KPC enzyme production, which in turn hydrolyzes and inactivates carbapenem antibiotics. KPC enzymes are a class A beta lactamases with several variants (KPC-2, KPC-3, etc) known. Various methods are used to detect specific portions of genes encoding KPC production. Carbapenemases can also be detected by other methods, including the modified Hodge test to detect carbapenemase production in isolates and minimum inhibitory concentration (MIC) to determine level of resistance. Source: Regenstrief LOINC

LP265773-4   Bacterial ABXBACT probe.amp.tar
PCR-based Methods for bacterial susceptibility are similar to genotyping for viral susceptibility, in that resistance or susceptibility is inferred based on the presence or absence of specific genetic information that is known to encode resistance to a specific antibiotic or group of antibiotics. For bacteria, resistance is often conferred by genes that are carried on plasmids, which can be transferred from one species to another. These genes encode proteins that specifically inhibit certain antibiotics, such as carbapenems or aminoglycosides. Source: Regenstrief LOINC

LP265774-2   Bacterial ABXBACT non-probe.amp.tar
PCR-based Methods for bacterial susceptibility are similar to genotyping for viral susceptibility, in that resistance or susceptibility is inferred based on the presence or absence of specific genetic information that is known to encode resistance to a specific antibiotic or group of antibiotics. For bacteria, resistance is often conferred by genes that are carried on plasmids, which can be transferred from one species to another. These genes encode proteins that specifically inhibit certain antibiotics, such as carbapenems or aminoglycosides. Source: Regenstrief LOINC

Fully-Specified Name

Component
Bacterial carbapenem resistance blaKPC gene
Property
PrThr
Time
Pt
System
Bld.pos growth
Scale
Ord
Method
Non-probe.amp.tar

Additional Names

Short Name
blaKPC Bld Pos Ql NAA+non-probe
Display Name
Carbapenem resistance blaKPC gene NAA+non-probe Ql (Pos bld culture)
Consumer Name Alpha Get Info
Carbapenem resistance blaKPC gene, Infected blood

Example Answer List: LL4046-0

Source: BioFire Diagnostics LLC
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8
N/A LA4543-0

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.65
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Bakterielle Carbapenem-Resistenz blaKPC-Gen:Nachweis oder Schwellenwert:Zeitpunkt:Blut.positives Wachstum:Ordinal:Zielfragmentamplifikation mit Detektion ohne Sonde
es-ES Spanish (Spain) Gen bla(KPC):PrThr:Punto temporal:Sangre crecimiento positivo:Ord:Amplificación del objetivo no basado en sonda
es-MX Spanish (Mexico) Gen blaKPC de resistencia a carbapenémicos bacterianos:Presencia o umbral:Punto temporal:Hemocultivo positivo:Ordinal:Amplificación de ácidos nucleicos con detección sin sonda
fr-FR French (France) Résistance bactérienne aux carbapénèmases blaKPC gène:Présence/Seuil:Ponctuel:Hémoculture positive:Qualitatif:Non-PCR amplification de cible
it-IT Italian (Italy) Resistenza batterica ai carbapenemici, gene blaKPC:PrThr:Pt:Emocolture positive:Ord:Non-sonda.amp.tar
Synonyms: Amplificazione target non basata su sonda Gene blaKPC di resistenza batterica ai carbapenemici Presenza o Soglia Punto nel tempo (episodio) Sangue Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Suscettibilità agli antibiotici
zh-CN Chinese (China) 细菌碳青霉烯类耐药 blaKPC 基因:存在情况或阈值:时间点:血液.生长阳性:序数型:非探针法.基因扩增.靶向
Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 借助靶向扩增的非探针方法;借助靶向扩增的非探针法;非探针法.扩增.靶向 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 扩增型 扩增性 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抵抗力 抵抗性 时刻;随机;随意;瞬间 电阻 碳青霉烯类;碳青霉烯类抗生素 细菌性 细菌的 细菌碳青霉烯类（碳青霉烯类抗生素、碳青霉烯）耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型） blaKPC 基因;细菌碳青霉烯酶（碳青黴烯酶、碳青霉烯水解酶）耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型）blaKPC 基因 经过扩增的 耐性 脱氧核糖核酸探针 血;血液 血液.阳性生长;血培养阳性;阳性血培养;阳性血液培养;全血.生长阳性 遗传基因;遗传因子;吉恩;生物基因 阻力

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85788-8